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pentobarbital will lessen the extent or influence of netupitant/palonosetron by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Netupitant is mainly metabolized by CYP3A4; keep away from use in clients who will be chronically making use of a strong CYP3A4 inducerhealth and fitness facilities / rest Middle/nembu